Polynucleotides
Polynucleotide treatment may be considered for selected skin-quality and under-eye concerns following consultation and suitability assessment.
What Polynucleotides Are
Polynucleotides are purified biopolymer chains designed to support skin hydration and texture. Unlike volumising fillers, polynucleotides work gently within the skin tissue.
Treatment response and outcomes vary between individuals.
Concerns Discussed During Consultation
- Under-eye skin quality and delicate tissue hydration
- Early fine lines and crepey skin texture
- Overall skin dullness and hydration loss
Suitability & What to Expect
Suitability is evaluated during a comprehensive consultation reviewing medical history and expectations. Small, micro-injection points are used to distribute the formula into targeted skin layers.
Potential Downtime & Risks
Temporary localised swelling, redness, and minor bruising may occur post-procedure. Full written aftercare guidance is provided following your treatment session. Response and recovery timelines differ between individuals.
About Polynucleotide Treatments at Mona Aesthetics
Polynucleotides represent a bio-regenerative approach focused on cellular repair rather than instant physical volume. Composed of highly purified fish-derived DNA fraction chains, polynucleotide gels signal local fibroblasts to produce fresh collagen and elastin. This is particularly valuable for thin, compromised skin that lacks elastic rebound.
During your consultation in Central Leeds, Mona assesses under-eye tissue thickness, fine line density, and overall micro-vascular integrity. For patients with thin under-eye skin where traditional hyaluronic dermal fillers might draw excess water or cause puffiness, polynucleotides offer a lighter, non-volumizing alternative.
Post-treatment recovery involves localized swelling bumps around the injection sites that typically subside within 24 to 48 hours. Because results rely on biological collagen synthesis, tissue quality improves progressively over several weeks. We advise avoiding harsh topical acids or active serums for 72 hours post-procedure.
Selected Polynucleotides Results
A preview of skin quality improvements and hydration results.

Polynucleotides treatment result.
Frequently Asked Questions
What are polynucleotides and how do they differ from fillers?
Polynucleotides are biostimulatory gels made of purified DNA fragments. Unlike dermal fillers that physically space-occupy tissue to build volume, polynucleotides communicate at a cellular level to stimulate fibroblast activity and collagen synthesis.
Is polynucleotide treatment suitable for the under-eye area?
Yes, polynucleotides are frequently evaluated for delicate under-eye tissue where thin skin shows crepiness or dark hollows without risking fluid retention or puffiness associated with traditional tear trough fillers.
How soon can I expect to see improvements?
Because polynucleotides work via cellular signaling rather than immediate mechanical volume, skin quality changes develop gradually over 4 to 8 weeks as new collagen matrix matures.
How many sessions are typically required?
A standard regenerative series usually consists of 2 to 3 treatment sessions spaced 3 to 4 weeks apart, followed by maintenance every 6 to 9 months.
Are there specific contraindications for polynucleotides?
Because polynucleotide gels are derived from fish sources, individuals with known severe fish allergies or active skin infections in the treatment zone should avoid this procedure.
Book a Polynucleotide Consultation
Schedule your skin quality evaluation with Mona at Mona Aesthetics in Central Leeds.
Book a Polynucleotide Consultation